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Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital. 2018
Bin Huang, and
Yuting He, and
Xingyan Ma, and
Renxin Cai, and
Jianming Zeng, and
Yang Lu, and
Weizheng Zhang, and
Kai Lan, and
Sunmei E, and
Yi-Wei Tang, and
Barry N Kreiswirth, and
Cha Chen, and
Liang Chen
Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Next-generation sequencing of 6 mcr-1-harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1, the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.
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