-transparent.png){kind=logo}
Twenty-four patients with advanced prostatic cancer were treated with daily injections of the LHRH analogue ICI 118630 (Zoladex) for up to 2 1/2 years. Successful long-term suppression of LH (luteinising hormone) and testosterone was observed without any escape of testosterone. Immunoreactive LH concentrations rose significantly following the daily injection of LHRH analogue but there was no corresponding rise in testosterone concentrations, suggesting altered bioactivity of the LH. A long-term clinical response was obtained in 10 patients (41.6%) and the median duration of response in these patients was 25 months. Eight of the 10 had well to moderately differentiated tumours. The actuarial median survival of all patients was 22 months.
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
August 1979,
The Journal of urology,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
May 1951,
Medecine et hygiene,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
April 1980,
Cancer,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
April 1980,
Cancer,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
April 1985,
The Journal of urology,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
March 1986,
Obstetrics and gynecology,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
December 2011,
Expert review of pharmacoeconomics & outcomes research,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
January 1989,
Oncology,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
April 2003,
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie,
S R Ahmed, and
J B Grant, and
S M Shalet, and
A Howell, and
C B Costello, and
T Weatherson, and
N J Blacklock
September 1986,
The Journal of urology,
