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Plasma levels of beta-endorphin-like immunoreactivity (beta-ELI) were measured in premature infants with apnea (n = 11) and compared to those in nonapneic controls (n = 9). Naltrexone (1-3 mg/kg) was given to the infants with apnea, 6 of whom were also receiving methylxanthines. Chest wall movements, nasal airflow, transcutaneous PO2 and electrocardiogram were recorded for 4-6 h prior to and for 4-6 h after administration of naltrexone. Samples for beta-ELI were taken prior to and 1 h post naltrexone. beta-ELI levels were significantly higher (p less than 0.007) in infants with apnea of prematurity than in control infants. No significant difference was found in beta-ELI levels before and after naltrexone. Naltrexone did not decrease the incidence of apnea.
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
January 1990,
Developmental pharmacology and therapeutics,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
June 1993,
Clinical and investigative medicine. Medecine clinique et experimentale,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
June 1987,
Endocrinologia experimentalis,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
November 1984,
Methods and findings in experimental and clinical pharmacology,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
January 1987,
Alcohol and drug research,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
January 1984,
Masui. The Japanese journal of anesthesiology,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
October 1987,
Endocrinologia japonica,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
September 1985,
Revista espanola de fisiologia,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
March 1985,
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression,
M G MacDonald, and
I R Moss, and
G G Kefale, and
H M Ginzburg, and
R J Fink, and
L Chin
June 1988,
Endocrinologia experimentalis,
