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Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART). 2018
Benjamin Bruno Policicchio, and
Paola Sette, and
Cuiling Xu, and
George Haret-Richter, and
Tammy Dunsmore, and
Ivona Pandrea, and
Ruy M Ribeiro, and
Cristian Apetrei
Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Two SIVmac251-infected rhesus macaques received tenofovir/emtricitabine with raltegravir intensification. Viral rebound occurred during treatment and sequencing of reverse transcriptase and integrase genes identified multiple resistance mutations. Similar to HIV infection, antiretroviral-resistance mutations may occur in SIV-infected nonhuman primates receiving nonsuppressive ART. As ART administration to nonhuman primates is currently dramatically expanding, fueled by both cure research and the study of HIV-related comorbidities, viral resistance should be factored in the study design and data interpretation.
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