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The present study defines assay systems for vaccinia virus-reactive Lyt-1+2- T cells mediating various functions and investigates the positivity of L3T4 antigen on these Lyt-1+2- T cells as well as the role of L3T4 antigen in the activation of these T cells with respect to their functions. C3H/He mice were immunized against vaccinia virus by inoculating viable virus intraperitoneally (i.p.). Anti-vaccinia virus reactivity in lymphoid cells from these immunized mice was assessed by proliferative response, helper T cell activities involved in cytotoxic T lymphocyte (CTL) and B cell (antibody) responses, delayed type-hypersensitivity (DTH) response, and production of lymphokines such as interleukin 2 (IL2) and macrophage-activating factor (MAF). The results demonstrate that all of the above anti-vaccinia virus responses were mediated by Lyt-1+2- T cells and that these Lyt-1+2- T cells expressed L3T4 antigens on their cell surfaces. Moreover, such anti-vaccinia Lyt-1+2- T cell responses were inhibited in the presence of anti-L3T4 antigen antibody. These results indicate that there is a reciprocal relationship between Lyt-2 and L3T4 markers, and that L3T4 antigen is closely related to the activation of various functions of anti-vaccinia virus Lyt-1+2- T cells.
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
April 1986,
Proceedings of the National Academy of Sciences of the United States of America,
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
June 1988,
Journal of immunology (Baltimore, Md. : 1950),
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
December 1986,
European journal of immunology,
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
August 1987,
Journal of immunology (Baltimore, Md. : 1950),
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
April 1986,
Cellular immunology,
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
May 1988,
Cancer research,
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
July 1984,
Journal of immunology (Baltimore, Md. : 1950),
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
June 1988,
Journal of immunology (Baltimore, Md. : 1950),
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
June 1986,
Immunological reviews,
A Aoyama, and
T Yoshioka, and
S Sato, and
Y Mizushima, and
M Ogata, and
S Ueda, and
S Kato, and
H Fujiwara, and
T Hamaoka
May 1988,
Journal of immunology (Baltimore, Md. : 1950),
