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Variants of Friend erythroleukemia cells were isolated which produced a high frequency (98%) or low frequency (2%) of hemoglobinized cells after induction with dimethylsulfoxide. Repeated subcloning and sib selection allowed enrichment of different cell lines without the use of mutagens or drug selection. The cell lines do not differ in growth rates, plating efficiencies, or chromosome numbers. The differences in inducibility phenotype were stable for more than 260 cell generations. In addition to differences in induction by dimethylsulfoxide and butyric acid, the cell lines also differ in spontaneous rates of cell differentiation. These results suggest that differences in differentiation rates are an inherited property of cells which is amplified in the presence of nonphysiological inducing agents.
D E Axelrod, and
R Terry, and
F G Kern
January 1983,
Differentiation; research in biological diversity,
D E Axelrod, and
R Terry, and
F G Kern
June 1988,
The Journal of biological chemistry,
D E Axelrod, and
R Terry, and
F G Kern
December 1983,
The Journal of biological chemistry,
D E Axelrod, and
R Terry, and
F G Kern
February 1988,
Molecular and cellular biology,
D E Axelrod, and
R Terry, and
F G Kern
June 1984,
Proceedings of the National Academy of Sciences of the United States of America,
D E Axelrod, and
R Terry, and
F G Kern
June 1993,
Biochimica et biophysica acta,
D E Axelrod, and
R Terry, and
F G Kern
November 1985,
Cancer research,
D E Axelrod, and
R Terry, and
F G Kern
September 1979,
Diabetes,
D E Axelrod, and
R Terry, and
F G Kern
August 1975,
Journal of the Reticuloendothelial Society,
D E Axelrod, and
R Terry, and
F G Kern
December 1977,
Cell,
