BIOMAT Database Logo BIOMAT Database Logo

Chemokine regulation of innate lymphoid cell tissue distribution and function. 2018

Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Department of Molecular Medicine, Sapienza University of Rome, 00161-Rome, Italy.

Three groups of innate lymphoid cells (ILCs) can be defined based on transcription factor requirements, cytokine production profiles, and roles in immunity. Given their strategic anatomical location into barrier tissues and the ability to rapidly produce cytokines and to cross-talk with other immune and non-immune cells, ILCs play fundamental functions in tissue homeostasis and regulation of immune responses. Several members of the chemokine family influence ILC tissue localization in the correct microenvironment by regulating their release from the bone marrow as well as their homing and retention in the tissues. In this review, we discuss the recent advances on how chemokine regulation of ILC tissue-positioning and functional interaction with other cells play essential roles in tissue-specific regulation of innate and adaptive immune responses.

UI MeSH Term Description Entries
D007113 Immunity, Innate The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS. Immunity, Native,Immunity, Natural,Immunity, Non-Specific,Resistance, Natural,Innate Immune Response,Innate Immunity,Immune Response, Innate,Immune Responses, Innate,Immunity, Non Specific,Innate Immune Responses,Native Immunity,Natural Immunity,Natural Resistance,Non-Specific Immunity
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D006706 Homeostasis The processes whereby the internal environment of an organism tends to remain balanced and stable. Autoregulation
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D056704 Adaptive Immunity Protection from an infectious disease agent that is mediated by B- and T- LYMPHOCYTES following exposure to specific antigen, and characterized by IMMUNOLOGIC MEMORY. It can result from either previous infection with that agent or vaccination (IMMUNITY, ACTIVE), or transfer of antibody or lymphocytes from an immune donor (IMMUNIZATION, PASSIVE). Acquired Immunity,Hybrid Immunity,Adaptive Immune Response,Adoptive Immunity,Immunity, Adaptive,Hybrid Immunities,Immune Response, Adaptive,Immunity, Acquired,Immunity, Adoptive,Immunity, Hybrid,Response, Adaptive Immune
D018925 Chemokines Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. They can be divided into at least three structural branches: C; (CHEMOKINES, C); CC; (CHEMOKINES, CC); and CXC; (CHEMOKINES, CXC); according to variations in a shared cysteine motif. Chemokine,Chemotactic Cytokine,Chemotactic Cytokines,Cytokines, Chemotactic,Intercrine,Intercrines,Cytokine, Chemotactic

Related Publications

Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Taming the beast within: regulation of innate lymphoid cell homeostasis and function.
November 2013, Journal of immunology (Baltimore, Md. : 1950),
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells.
June 2016, European journal of immunology,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment.
January 2024, Advances in experimental medicine and biology,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Transcriptional regulation of innate lymphoid cell fate.
July 2015, Nature reviews. Immunology,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Neuronal regulation of innate lymphoid cell responses.
June 2022, Current opinion in immunology,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Innate lymphoid cell regulation of adaptive immunity.
October 2016, Immunology,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Innate lymphoid cell sensing of tissue vitality.
February 2019, Current opinion in immunology,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
December 2017, The Journal of experimental medicine,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Lipid regulation of group 2 innate lymphoid cell function: Moving beyond epithelial cytokines.
May 2018, The Journal of allergy and clinical immunology,
Alessandra Soriani, and Helena Stabile, and Angela Gismondi, and Angela Santoni, and Giovanni Bernardini
Editorial: Innate lymphoid cell development, migration, and function.
January 2023, Frontiers in immunology,
Copied contents to your clipboard!