-transparent.png){kind=logo}
The administration of the D1 DA receptor antagonist SCH 23390 produces catalepsy in rat, and this behavior can be abolished by pretreatment with selective D2 DA receptor agonists. The administration of mixed D1/D2 DA agonists, but not of selective D2 DA agonists, produces SMB behavior in monkeys with surgical unilateral VMT lesions of the brain stem. The DA agonist-induced SMB behavior is abolished by pretreatment of the monkeys with either the D1 DA antagonist SCH 23390 or with the mixed D1/D2 antagonist fluphenazine, but not with the selective D2 antagonist (+/-) sulpiride. A hypothetical relationship between abnormal guanine nucleotide metabolism in Lesch-Nyhan syndrome and the development of DA receptor supersensitivity is presented. The possible role of abnormal guanine nucleotide metabolism in some mental disorders associated with DA dysfunctions is discussed.
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
January 1990,
Synapse (New York, N.Y.),
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
January 1991,
Therapie,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
January 2001,
International review of neurobiology,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
April 1999,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
March 1991,
European journal of pharmacology,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
March 2014,
Veterinary research communications,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
October 2009,
The international journal of neuropsychopharmacology,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
September 1990,
Cellular and molecular neurobiology,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
October 1992,
Brain research. Developmental brain research,
M Goldstein, and
S Kuga, and
Y Shimizu, and
E Meller
December 2007,
The European journal of neuroscience,
