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A modified fibrin-agar overlay assay was used to measure the fibrinolytic activity in human cervical epithelial cells. The fibrinolytic activity results from a cell-associated serine protease that acts as a plasminogen activator. An enzymatic and morphologic comparison of individual normal and abnormal cells reveals that about 50% of the dysplastic and carcinoma in situ cells contain high levels of the activator. Forty percent of morphologically normal metaplastic cells also exhibit high activities of plasminogen. Forty percent of morphologically normal metaplastic cells also exhibit high activities of plasminogen activator. Most normal intermediate and superficial epithelial cells and all erythrocytes and leukocytes are inactive. The frequency of plasminogen activator-containing cells was somewhat higher in cytomorphologically abnormal samples than in normal samples.
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
February 1986,
Japanese journal of cancer research : Gann,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
December 2014,
Experimental gerontology,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
January 1988,
The Prostate,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
January 2014,
PloS one,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
September 1981,
Cancer,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
November 1994,
British journal of cancer,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
January 1993,
Thrombosis research,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
November 1983,
The Journal of investigative dermatology,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
November 1984,
Biochimica et biophysica acta,
R H Jensen, and
W L Bigbee, and
A L Zimmerman, and
E B King
October 2005,
British journal of cancer,
