-transparent.png){kind=logo}
In order to clarify the beneficial effect of donor-specific blood transfusions (DST) on kidney allograft survival, sera from 16 patients treated with DST were studied using the mixed lymphocyte culture (MLC) serum inhibition test. The results demonstrate that MLC inhibitory factors could be induced in the serum of the recipients after the completion of DST, and that these factors are directed against cells of the recipient but not against cell from the donor. Regarding the correlation with rejection episodes and clinical outcome, a significant improvement in renal transplant survival and reduction in rejection episodes was observed when MLC inhibitory factors were present in post-DST sera. These data suggest that such factors may contain antibodies directed against recognition sites on T lymphocytes, e.g., anti-idiotypic antibodies, and be associated with prolonged graft survival of living-related, high MLC-reactive one-haplotype-mismatched kidney.
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
May 1995,
The Journal of surgical research,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
March 1981,
Transplantation proceedings,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
September 1981,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
January 1980,
Proceedings of the Clinical Dialysis and Transplant Forum,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
February 1989,
Transplantation proceedings,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
January 2018,
Clinical journal of the American Society of Nephrology : CJASN,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
February 1989,
Transplantation proceedings,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
February 1987,
Transplantation proceedings,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
June 2008,
Transplantation proceedings,
K Sakagami, and
H Takeuchi, and
T Matsumoto, and
K Tsuboi, and
H Ohsaki, and
K Tanaka, and
K Ohiwa, and
K Orita
November 2000,
Transplantation proceedings,
