BIOMAT Database Logo BIOMAT Database Logo

Cardiac hormones: morphology and biochemistry. 1986

W G Forssmann, and D Hock, and V Mutt

The heart contains, in addition to its myocardial working cells and the conductive system, a specialized endocrine part localized mainly in the atrial appendage which is predominantly made up by myoendocrine cells. The ultrastructural and immunocytochemical analysis of myoendocrine cells show a specialized secretory apparatus involved in the synthesis and secretion of cardiac hormones. These cardiac hormones are synthesized and processed in the myoendocrine cells as follows: a preprohormone is found in the rough endoplasmic reticulum, the prohormone cardiodilatin/gamma-atrial natriuretic polypeptide (CDD/ANP) is processed in the Golgi apparatus and stored in the secretory granules. The circulating peptide, cardiodilatin 99-126/alpha-ANP, is the C-terminus of this preprohormone which is released as the active circulating form into the blood stream.

UI MeSH Term Description Entries
D007120 Immunochemistry Field of chemistry that pertains to immunological phenomena and the study of chemical reactions related to antigen stimulation of tissues. It includes physicochemical interactions between antigens and antibodies.
D009124 Muscle Proteins The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN. Muscle Protein,Protein, Muscle,Proteins, Muscle
D009320 Atrial Natriuretic Factor A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS. ANF,ANP,Atrial Natriuretic Peptide,Atrial Natriuretic Peptides,Atriopeptins,Auriculin,Natriuretic Peptides, Atrial,ANF (1-126),ANF (1-28),ANF (99-126),ANF Precursors,ANP (1-126),ANP (1-28),ANP Prohormone (99-126),ANP-(99-126),Atrial Natriuretic Factor (1-126),Atrial Natriuretic Factor (1-28),Atrial Natriuretic Factor (99-126),Atrial Natriuretic Factor Precursors,Atrial Natriuretic Factor Prohormone,Atrial Natriuretic Peptide (1-126),Atrial Pronatriodilatin,Atriopeptigen,Atriopeptin (1-28),Atriopeptin (99-126),Atriopeptin 126,Atriopeptin Prohormone (1-126),Cardiodilatin (99-126),Cardiodilatin Precursor,Cardionatrin I,Cardionatrin IV,Prepro-ANP,Prepro-CDD-ANF,Prepro-Cardiodilatin-Atrial Natriuretic Factor,Pro-ANF,ProANF,Proatrial Natriuretic Factor,Pronatriodilatin,alpha ANP,alpha-ANP Dimer,alpha-Atrial Natriuretic Peptide,beta-ANP,beta-Atrial Natriuretic Peptide,gamma ANP (99-126),gamma-Atrial Natriuretic Peptide,Natriuretic Peptide, Atrial,Peptide, Atrial Natriuretic,Peptides, Atrial Natriuretic,Prepro ANP,Prepro CDD ANF,Prepro Cardiodilatin Atrial Natriuretic Factor,Pro ANF,alpha ANP Dimer,alpha Atrial Natriuretic Peptide,beta ANP,beta Atrial Natriuretic Peptide,gamma Atrial Natriuretic Peptide
D003594 Cytoplasmic Granules Condensed areas of cellular material that may be bounded by a membrane. Cytoplasmic Granule,Granule, Cytoplasmic,Granules, Cytoplasmic
D006056 Golgi Apparatus A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990) Golgi Complex,Apparatus, Golgi,Complex, Golgi
D006325 Heart Atria The chambers of the heart, to which the BLOOD returns from the circulation. Heart Atrium,Left Atrium,Right Atrium,Atria, Heart,Atrium, Heart,Atrium, Left,Atrium, Right
D006651 Histocytochemistry Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods. Cytochemistry
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

W G Forssmann, and D Hock, and V Mutt
Cardiac hormones. I. Review on the morphology, biochemistry, and molecular biology of the endocrine heart.
December 1986, European journal of clinical investigation,
W G Forssmann, and D Hock, and V Mutt
Morphology and biochemistry.
March 1983, Acta morphologica Neerlando-Scandinavica,
W G Forssmann, and D Hock, and V Mutt
Changes in skeletal muscle morphology and biochemistry after cardiac transplantation.
March 1997, The American journal of cardiology,
W G Forssmann, and D Hock, and V Mutt
Biochemistry of the hormones.
January 1948, Annual review of biochemistry,
W G Forssmann, and D Hock, and V Mutt
[Biochemistry of female hormones].
January 1966, Acta gynaecologica et obstetrica Hispano-Lusitana,
W G Forssmann, and D Hock, and V Mutt
[Adrenal hormones; biochemistry, pharmacology].
August 1953, Minerva medica,
W G Forssmann, and D Hock, and V Mutt
Morphology and Biochemistry of Ovulation.
June 2021, Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia,
W G Forssmann, and D Hock, and V Mutt
Biochemistry and physiology of thyroid hormones.
January 1963, New York state journal of medicine,
W G Forssmann, and D Hock, and V Mutt
Biochemistry of A.C.T.H. and adrenocortical hormones.
January 1955, International archives of allergy and applied immunology,
W G Forssmann, and D Hock, and V Mutt
[Biochemistry and physiology of hypothalamic hormones].
January 1965, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
Copied contents to your clipboard!