-transparent.png){kind=logo}
Sensitivity, Specificity, and Public-Health Utility of Clinical Case Definitions Based on the Signs and Symptoms of Cholera in Africa. 2018
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
Agence de Medecine Préventive, Paris, France.
During 2014, Africa reported more than half of the global suspected cholera cases. Based on the data collected from seven countries in the African Cholera Surveillance Network (Africhol), we assessed the sensitivity, specificity, and positive and negative predictive values of clinical cholera case definitions, including that recommended by the World Health Organization (WHO) using culture confirmation as the gold standard. The study was designed to assess results in real-world field situations in settings with recent cholera outbreaks or endemicity. From June 2011 to July 2015, a total of 5,084 persons with suspected cholera were tested for Vibrio cholerae in seven different countries of which 35.7% had culture confirmation. For all countries combined, the WHO case definition had a sensitivity = 92.7%, specificity = 8.1%, positive predictive value = 36.1%, and negative predictive value = 66.6%. Adding dehydration, vomiting, or rice water stools to the case definition could increase the specificity without a substantial decrease in sensitivity. Future studies could further refine our findings primarily by using more sensitive methods for cholera confirmation.
Related Publications
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
January 1989,
American journal of public health,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
July 1988,
American journal of public health,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
May 2009,
Science (New York, N.Y.),
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
June 2015,
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
September 2008,
Statistics in medicine,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
January 2015,
Fatigue : biomedicine, health & behavior,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
July 2023,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
January 2009,
Medecine et maladies infectieuses,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
February 1991,
American journal of public health,
Johara Nadri, and
Delphine Sauvageot, and
Berthe-Marie Njanpop-Lafourcade, and
Cynthia S Baltazar, and
Abiba Banla Kere, and
Godfrey Bwire, and
Daouda Coulibaly, and
Adele Kacou N'Douba, and
Atek Kagirita, and
Sakoba Keita, and
Lamine Koivogui, and
Dadja E Landoh, and
Jose P Langa, and
Berthe N Miwanda, and
Guy Mutombo Ndongala, and
Elibariki R Mwakapeje, and
Jacob L Mwambeta, and
Martin A Mengel, and
Bradford D Gessner
March 2020,
The Lancet. Infectious diseases,
