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In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution. 2019
Alexandra Barbouti, and
Konstantinos Evangelou, and
Ioannis S Pateras, and
Alexandra Papoudou-Bai, and
Amalia Patereli, and
Kalliopi Stefanaki, and
Dimitra Rontogianni, and
Daniel Muñoz-Espín, and
Panagiotis Kanavaros, and
Vassilis G Gorgoulis
Department of Anatomy-Histology-Embryology, Medical School, University of Ioannina, Ioannina, Greece.
Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ, that cellular senescence occurs during human thymic involution using SenTraGor™, a novel chemical compound that is applicable in archival tissue material, providing thus further insights in thymus histophysiology.
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