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A single high dose of streptozotocin was found to cause a transient increase in islet capillary permeability 2-4 h after administration. Staining of areas of increased vascular permeability by Evans blue showed that islets, but not exocrine tissue, were affected. The permeability increase seems to involve vasoactive substances released by mast cells. A mast cell inhibitor (disodium cromoglycate) and a serotonin antagonist (methysergide) were found protective. Furthermore, administration of methysergide partially prevented the development of hyperglycaemia in streptozotocin-treated rats. In mice, almost full protection from diabetes development was reached by both methysergide and disodium cromoglycate. Our observations indicate an important role of mast cell controlled membrane permeability in this model of beta-cell destruction and diabetes development.
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
October 1967,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
November 1974,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
May 1963,
Cancer chemotherapy reports,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
May 1963,
Cancer chemotherapy reports,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
June 2016,
Biomedica : revista del Instituto Nacional de Salud,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
November 1969,
The Journal of clinical investigation,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
February 1985,
Methods and findings in experimental and clinical pharmacology,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
December 1985,
Biochemical medicine,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
August 2005,
Neuro endocrinology letters,
H Beppu, and
K Maruta, and
T Kürner, and
H Kolb
March 1998,
Transplantation proceedings,
