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We have investigated the specificities of antibrain antibodies in the sera of patients with senile dementia of the Alzheimer's type (SDAT). Using indirect immunofluorescence, we observed a vascular pattern of staining in 6 of 16 sera from patients with typical SDAT. None of 14 sera from age matched controls demonstrated this pattern of staining. The vascular pattern of staining seen with SDAT sera was identical to the immunofluorescent staining of brain by a monoclonal antibody to vascular basement membrane heparan sulfate proteoglycan. Immunoabsorption of SDAT sera with purified vascular proteoglycan abolished the staining of brain vessels. Using an enzyme linked immunoassay, 3 of the 6 vascular-reactive SDAT sera, and none of the 24 sera from aged controls, were shown to contain antibodies to purified vascular heparan sulfate proteoglycan. Proteoglycans play an important role in the barrier function of the blood-brain barrier. Autoimmune injury to the blood-brain barrier by antivascular antibody may play a role in the pathogenesis of dementia by permitting the passage of injurious substances into the brain.
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
September 1992,
Journal of clinical pathology,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
January 1979,
Research publications - Association for Research in Nervous and Mental Disease,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
May 1987,
Psychiatry research,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
December 1984,
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H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
June 1997,
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
April 1995,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
January 1986,
American journal of preventive medicine,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
January 1993,
Neurobiology of aging,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
November 1989,
Methods and findings in experimental and clinical pharmacology,
H M Fillit, and
E Kemeny, and
V Luine, and
M E Weksler, and
J B Zabriskie
March 1998,
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
