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Sixty-one patients with refractory or relapsed or secondary acute leukemia were treated with high-dose cytosine arabinoside (2-3 g/sq m in intravenous infusion every 12 hr to a 12-36 g/sq m total dose). m-Amsa or another antileukemic drug was given with cytosine arabinoside to 20 patients. Complete remission was achieved in 12 of 27 patients with acute myeloid leukemia, 5 of 8 patients with chemotherapy-induced leukemia, 3 of 7 patients with hematologic disorders in blastic crisis and 5 of 17 acute lymphoblastic leukemia patients. A similar response rate (6/16) was obtained when m-Amsa was given with cytosine-arabinoside. The median duration of remission was short (4 months in acute myeloid leukemia). Bone marrow transplantation was performed in 10 patients during the remission time. This regimen has acceptable toxicity; severe neurologic or hepatic disorders occurred in 18% of patients. These data suggest that high-dose cytosine arabinoside is an effective alternative in the treatment of resistant acute leukemia.
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
June 1985,
Seminars in oncology,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
June 1985,
Seminars in oncology,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
June 1987,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
January 1984,
American journal of hematology,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
October 1979,
Cancer,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
December 1984,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
August 1984,
Ugeskrift for laeger,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
June 1985,
Presse medicale (Paris, France : 1983),
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
December 1986,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
F Witz, and
D Olive, and
P Lederlin, and
P Bordigoni, and
X Troussard, and
B Grosbois, and
G Schaison, and
G Cornu
January 1985,
Neoplasma,
