BACKGROUND Inhaled nitrous oxide (MEOPA) ensures short-term analgesia of a patient in spontaneous ventilation through a mask. It ensures analgesic coverage during the painful gesture while saving to the patient the phenomena of memorization. OBJECTIVE To study the efficacy and safety of the use of MEOPA during the make stitches. METHODS Randomized double blind prospective study including any patient aged > 16 years admitted to the emergency for make stitches during a period of 3 months. After consent, patients were randomized to 2 groups (MEOPA versus placebo). When the stitches were made, if the patient has a VAS (visual analog scale) > 30%, an emergency analgesia with 2% subcutaneous xylocaine is performed. The primary endpoint was the degree of analgesia according to VAS. The secondary endpoints were the occurrence of side effects, patient and operator satisfaction. RESULTS We collected 115 patients comparable in age, sex and pain at baseline. The mean of the VAS during suturing was 11.1±5.8% (MEOPA) versus 47.8±13.9% (placebo); and the mean at the end of the procedure was 5.2±5% (MEOPA) versus 27.6±12.8% (placebo) with p=0.000. Only minor adverse events (22% versus 16%) were observed with P = 0.306. CONCLUSIONS We affirm the interest of this non-invasive, safe, innocuous analgesic technique that satisfies caregivers, patients and caregivers in suturing.