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Chemical inflammation was induced subcutaneously in 10 rats using carrageenan mucopolysaccharide. Dual spin echo (SE) imaging of inflammatory loci was performed employing a 0.35 tesla resistive magnet. In addition, gadolinium-DTPA was administrated intravenously into 5 rats to evaluate the potential benefits of paramagnetic contrast medium for the detection and characterization of inflammatory loci. T2 weighted SE images demonstrated the edematous lesions as zones of high intensity. This was attributed to the increased relaxation times of lesions when compared to the adjacent soft tissue. The inflammation was also delineated on T1 weighted SE images, but only after injection of paramagnetic Gd-DTPA. Carrageenan mucopolysaccharide-induced lesions provide a useful experimental model for in vivo evaluation of soft tissue inflammation using magnetic resonance imaging. No special benefit of paramagnetic contrast enhancement was demonstrated in this model of local edema.
H Paajanen, and
R C Brasch, and
U Schmiedl, and
M Ogan
May 1990,
Acta radiologica (Stockholm, Sweden : 1987),
H Paajanen, and
R C Brasch, and
U Schmiedl, and
M Ogan
January 1987,
Acta radiologica (Stockholm, Sweden : 1987),
H Paajanen, and
R C Brasch, and
U Schmiedl, and
M Ogan
January 1987,
Acta radiologica (Stockholm, Sweden : 1987),
H Paajanen, and
R C Brasch, and
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M Ogan
December 1992,
Acta medica Okayama,
H Paajanen, and
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M Ogan
January 1988,
Skeletal radiology,
H Paajanen, and
R C Brasch, and
U Schmiedl, and
M Ogan
July 1988,
Investigative radiology,
H Paajanen, and
R C Brasch, and
U Schmiedl, and
M Ogan
January 1987,
Neurosurgical review,
H Paajanen, and
R C Brasch, and
U Schmiedl, and
M Ogan
January 1994,
Acta neurochirurgica. Supplementum,
H Paajanen, and
R C Brasch, and
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M Ogan
January 1991,
Gastrointestinal radiology,
H Paajanen, and
R C Brasch, and
U Schmiedl, and
M Ogan
May 1990,
Ophthalmology,
