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Bone marrow from normal and chronic myeloid leukemia donors was grown in liquid cultures without feeder layers and with and without 12-u-tetradecanoyl-phorbol-13-acetate (TPA). In 24-96 hours most of the cells (60-70%) cultured with 10(-7) M and 10(-8) M TPA stuck to the bottom of the flasks and had a peculiar shape resembling macrophages possessing strong phagocytizing activity and surface markers of monocyte-macrophage lineage of differentiation. 10(-7) M and 10(-8) M TPA fully inhibited CFU(c) in cultures of normal marrow as well as of chronic myeloid leukemia (CML) patients; 10(-9) M and 10(-10) M exhibited individually varied partial suppression. Cultivation of bone marrow with 10(-11) M to 10(-13) M TPA led in some cases to statistically significant increase of CFU(c) on day 4 and day 7.
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
November 1987,
Cancer letters,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
February 1985,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
January 1979,
Experimental hematology,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
October 1991,
Cancer research,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
November 1980,
The Journal of clinical investigation,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
June 1979,
Proceedings of the National Academy of Sciences of the United States of America,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
February 1985,
Proceedings of the National Academy of Sciences of the United States of America,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
October 1984,
Experimental hematology,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
January 1984,
Acta haematologica,
I A Svet-Moldavskaya, and
S N Zinzar, and
G J Svet-Moldavsky, and
P E Mann, and
J G Bekesi, and
J F Holland, and
B D Clarkson, and
Z Arlin, and
B Koziner
November 1981,
Cancer research,
