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Two hundred sixty-eight patients with mild to moderate acne vulgaris completed a multicenter, double-blind, controlled study comparing isotretinoin 0.05% gel with its vehicle. Patients were treated twice daily for up to 14 weeks. Efficacy was measured by counting facial inflammatory and noninflammatory lesions and by grading acne severity initially and at 2- to 3-week intervals throughout the study. The isotretinoin 0.05% gel proved to be statistically more effective than vehicle in reducing inflammatory lesions after 5 weeks and in reducing noninflammatory lesions and acne severity grade after 8 weeks. Except for two patients who dropped out because of irritation, isotretinoin 0.05% gel was well tolerated.
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
May 1992,
Clinical and experimental dermatology,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
September 2002,
The British journal of dermatology,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
January 2014,
Advanced biomedical research,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
March 1991,
Journal of the American Academy of Dermatology,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
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W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
January 1999,
Dermatology (Basel, Switzerland),
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
January 2003,
Indian journal of dermatology, venereology and leprology,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
January 2007,
Indian journal of dermatology, venereology and leprology,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
May 2009,
Journal of the European Academy of Dermatology and Venereology : JEADV,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
May 1981,
International journal of dermatology,
D K Chalker, and
J L Lesher, and
J G Smith, and
H C Klauda, and
P E Pochi, and
W S Jacoby, and
D M Yonkosky, and
J J Voorhees, and
C N Ellis, and
S Matsuda-John
January 2010,
Indian journal of dermatology, venereology and leprology,
