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Previous reports from this laboratory described animal experiments in which intravenous administration of fructose 1-6 diphosphate (FDP) at the onset of hypovolemia, toxemia, and trauma effected improvement in hemodynamic and metabolic parameters, attenuation of tissue damage, and a significant increase in survival. The obvious question remained: Would this agent be as effective if administered after the onset of the shock syndrome? Thus 72 anesthetized dogs were subjected to normotensive hemorrhagic shock and were subsequently treated with FDP at 30 minutes, 1 hour, 90 minutes, and 2 hours after exsanguination. Analysis of the results (as compared with vehicle-treated controls) revealed evidence of improved cardiac output and arterial pressure (p less than 0.02), conservation of effective circulatory volume, better oxygen utilization, and a significant increase in survival (p less than 0.0001). These results, in conjunction with earlier experimental and recent clinical data, indicate that the therapeutic effect of FDP in ischemic and hypoperfusion states is in part metabolically mediated by the augmentation of carbohydrate utilization. Prevention of tissue injury is in part due to the inhibition of generation of oxygen-derived free radicals by neutrophils.
A K Markov, and
J Terry, and
T Z White, and
R H Didlake, and
H K Hellems
January 1966,
Surgery, gynecology & obstetrics,
A K Markov, and
J Terry, and
T Z White, and
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H K Hellems
January 1958,
Surgical forum,
A K Markov, and
J Terry, and
T Z White, and
R H Didlake, and
H K Hellems
January 1985,
Circulatory shock,
A K Markov, and
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R H Didlake, and
H K Hellems
January 1990,
Comparative immunology, microbiology and infectious diseases,
A K Markov, and
J Terry, and
T Z White, and
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H K Hellems
September 1964,
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A K Markov, and
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H K Hellems
May 1999,
Chinese journal of traumatology = Zhonghua chuang shang za zhi,
A K Markov, and
J Terry, and
T Z White, and
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H K Hellems
August 1955,
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A K Markov, and
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H K Hellems
January 1973,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
A K Markov, and
J Terry, and
T Z White, and
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H K Hellems
August 1968,
Metabolism: clinical and experimental,
A K Markov, and
J Terry, and
T Z White, and
R H Didlake, and
H K Hellems
December 1975,
The Journal of surgical research,
