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Specific insulin-like growth factor I (IGF-I) receptors on the Madin-Darby canine kidney (MDCK) cell line were identified and characterized. [125I]IGF-I specifically bound to the cells, but [125I]insulin bindings to the cells was minimal. Unlabeled IGF-I displaced both the IGF-I and insulin bindings with potencies that were 100 and 10 times as great as insulin. By an affinity labeling technique, IGF type I receptors were present in the MDCK cells. IGF-I stimulated DNA synthesis and cell proliferation at physiological concentrations. On the other hand, insulin had a little effect on DNA synthesis. These data suggest that IGF type I receptors as demonstrated in MDCK cells are involved in DNA synthesis and cell proliferation.
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
January 1986,
Biochemical and biophysical research communications,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
July 1979,
Proceedings of the National Academy of Sciences of the United States of America,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
November 1984,
The EMBO journal,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
March 1986,
The EMBO journal,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
January 1991,
Molecular endocrinology (Baltimore, Md.),
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
October 1988,
Biochimica et biophysica acta,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
October 1989,
Biochimica et biophysica acta,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
October 2023,
Journal of applied microbiology,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
July 2005,
Pflugers Archiv : European journal of physiology,
I Sukegawa, and
N Hizuka, and
K Takano, and
K Asakawa, and
K Shizume
August 1992,
Journal of the American Society of Nephrology : JASN,
