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Synthesis and Evaluation of O2-Derived Diazeniumdiolates Activatable via Bioorthogonal Chemistry Reactions in Living Cells. 2018
Tian Lv, and
Jianbing Wu, and
Fenghua Kang, and
Tingting Wang, and
Boheng Wan, and
Jin-Jian Lu, and
Yihua Zhang, and
Zhangjian Huang
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Jiangsu Key Laboratory of Drug Screening , China Pharmaceutical University , Nanjing 210009 , P. R. China.
A class of O2-alkyl derived diazeniumdiolates 3a-f and 4a-c were designed and synthesized as new bioorthogonal NO precursors, which can be effectively uncaged in the presence of a palladium catalyst via bioorthogonal bond cleavage reactions to generate NO in living cancer cells, eliciting potent antiproliferative activity.
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