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Atrial natriuretic peptide (ANP), besides its diuretic and antihypertensive effects, exhibits an "in vitro" inhibitory action on aldosterone. In order to elucidate if these effects are present also "in vivo", we injected 100 micrograms of alpha-human ANP as a bolus in normal volunteers, low renin essential hypertensive subjects (LRH) and in patients with primary aldosteronism (PA). A transient hypotensive effect was seen in all patients, without significant variations of heart rate. The diuretic and saluretic effects of ANP were greater in hypertensive subjects, even in PA where endogenous ANP levels are known to be elevated. Plasma aldosterone values decreased significantly only in normal volunteers. In conclusion, in LRH and PA renal effects of ANP are not diminished, although its aldosterone-inhibiting properties are less evident than in normals.
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
November 1990,
Kidney international. Supplement,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
October 1986,
The Journal of clinical endocrinology and metabolism,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
January 1985,
Hypertension (Dallas, Tex. : 1979),
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
January 1991,
Clinical and experimental hypertension. Part A, Theory and practice,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
September 1987,
Mayo Clinic proceedings,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
January 2009,
Clinical laboratory,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
January 1974,
The Netherlands journal of medicine,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
February 1975,
Archives of internal medicine,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
December 2006,
Journal of hypertension,
F Mantero, and
S Rocco, and
F Pertile, and
G Carpenè, and
F Fallo, and
L Leone, and
M Boscaro
September 1988,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
