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The effect of posture on plasma atrial natriuretic peptide (ANP) levels during a constant iv infusion of the 28-amino acid polypeptide was investigated in 8 normal men. alpha-Human ANP was infused at a constant rate of 0.5 micrograms/min (162 pmol/min) while the men were supine, then erect, and finally when supine again. Plasma ANP levels rose from 10.9 +/- 1.6 (+/- SEM) to 33.3 +/- 2.4 pmol/L after 60 min of constant infusion with the men in the supine position. On standing, plasma ANP increased further to 40.6 +/- 3.4 pmol/L, then fell to 32.2 +/- 2.7 pmol/L with resumption of supine posture. The calculated MCR of ANP fell from a mean of 7.7 to 5.7 L/min on standing, but rose again to 7.6 L/min upon lying down. We conclude that body posture has a significant effect on the rate of clearance of ANP from plasma.
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
September 1986,
Clinical science (London, England : 1979),
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
January 1985,
Lancet (London, England),
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
January 1989,
Clinical and experimental hypertension. Part A, Theory and practice,
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
February 1987,
Clinical science (London, England : 1979),
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
January 1988,
Zeitschrift fur Kardiologie,
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
May 1990,
The American journal of physiology,
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
November 1987,
European journal of pharmacology,
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
September 1993,
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
January 1988,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
A H Gillies, and
I G Crozier, and
M G Nicholls, and
E A Espiner, and
T G Yandle
February 1991,
Acta physiologica Scandinavica,
