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Six of 12 children with Down syndrome (DS) tested by means of long-term tape-recordings of oxygen saturation, breathing movements and expired CO2 were found to have previously undetected and severe upper airway obstruction during sleep. In five cases the obstruction occurred in the pharynx and in the sixth it was due to bilateral choanal stenosis. When compared with age-matched controls, overnight tape-recordings showed episodes of abnormal arterial hypoxaemia and an abnormally elevated end-tidal CO2. Episodes of obstruction were most marked during sleep associated with a non-regular breathing pattern. Abnormal episodes of hypoxaemia were associated with continued breathing movements. Sometimes there was no airflow (complete obstruction); at other times airflow continued normally or was reduced in amplitude (partial obstruction). During episodes of partial or complete airway obstruction the inspiratory waveform showed a characteristic shape. These results show sleep-related upper airway obstruction to be an often undetected complication of DS and all necessary measures should be taken to overcome the obstruction when it reaches the stage of producing abnormal hypoxaemia. Choanal dilatation and tracheostomy were successful in treating two of the children. Tonsillectomy and adenoidectomy were successful for one child, but only of marginal benefit for two others.
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
May 1993,
Archives of disease in childhood,
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
September 1996,
Archives of otolaryngology--head & neck surgery,
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
June 1988,
British medical journal (Clinical research ed.),
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
June 1979,
The Laryngoscope,
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
February 2005,
Anales de pediatria (Barcelona, Spain : 2003),
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
November 1996,
The Journal of pediatrics,
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
November 1978,
The Journal of pediatrics,
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
October 2003,
Clinical reviews in allergy & immunology,
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
January 1978,
The Journal of laryngology and otology,
D P Southall, and
V A Stebbens, and
R Mirza, and
M H Lang, and
C B Croft, and
E A Shinebourne
December 2023,
Pediatric research,
