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Administration of L-DOPA, a precursor of dopamine, induced EEG activation, arousal and signs of behavioral excitation in the rabbit. The effects were fully prevented by pretreatment with minute doses (0.01 mg/kg i.v.) of the selective D-1 antagonist SCH 23390. Conversely, its S-enantiomer SCH 23388, which has weak actions on D-1 receptors, displayed relatively low inhibition of L-DOPA effects. (-)-Sulpiride (12.5 mg/kg), a selective D-2 antagonist, and haloperidol (0.1-0.3 mg/kg), a neuroleptic that interacts preferentially with D-2 receptors, both inhibited behavioral effects but failed to block EEG activation. The data indicate that D-1 receptors play an essential role in mediating EEG activation induced by L-DOPA.
E Ongini, and
M G Caporali, and
V G Longo
December 1985,
European journal of pharmacology,
E Ongini, and
M G Caporali, and
V G Longo
December 1984,
Neuropharmacology,
E Ongini, and
M G Caporali, and
V G Longo
March 1987,
European journal of pharmacology,
E Ongini, and
M G Caporali, and
V G Longo
March 1984,
European journal of pharmacology,
E Ongini, and
M G Caporali, and
V G Longo
February 1985,
European journal of pharmacology,
E Ongini, and
M G Caporali, and
V G Longo
April 1984,
European journal of pharmacology,
E Ongini, and
M G Caporali, and
V G Longo
January 1986,
Advances in experimental medicine and biology,
E Ongini, and
M G Caporali, and
V G Longo
January 1986,
Psychopharmacology bulletin,
E Ongini, and
M G Caporali, and
V G Longo
July 1989,
Japanese journal of pharmacology,
E Ongini, and
M G Caporali, and
V G Longo
September 1984,
Naunyn-Schmiedeberg's archives of pharmacology,
