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In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions. 2018
Hamed Fakhim, and
Afsane Vaezi, and
Eric Dannaoui, and
Cheshta Sharma, and
Bita Mousavi, and
Anuradha Chowdhary, and
Jacques F Meis, and
Hamid Badali
Department of Medical Parasitology and Mycology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran; Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: fakhiim.hamed@gmail.com.
In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n=31) and -susceptible (n=2) isolates. Interaction was synergistic for only 1 resistant isolate carrying the TR34/L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates.
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