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N-Heterocyclic Carbene-Catalyzed Annulation of α-Chloroaldehydes with γ-/δ-Amino-α,β-Unsaturated Ketones: Enantioselective Synthesis of Pyrrolidones and Piperidones. 2018

Zhao-Fei Zhang, and Chun-Lin Zhang, and Zhi-Yong Song, and Zhong-Hua Gao, and Song Ye
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

The N-heterocyclic carbene-catalyzed [2+3] and [2+4] annulations of α-chloroaldehydes with γ-/δ-amino-α,β-unsaturated ketones were developed, giving the corresponding pyrrolidones and piperidones in good yields with exclusive trans-selectivities and excellent enantioselectivities.

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