BIOMAT Database Logo BIOMAT Database Logo

Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. 2018

David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.

Reciprocal interactions between the prefrontal cortex (PFC) and thalamus play a critical role in cognition, but the underlying circuits remain poorly understood. Here we use optogenetics to dissect the specificity and dynamics of cortico-thalamo-cortical networks in the mouse brain. We find that cortico-thalamic (CT) neurons in prelimbic PFC project to both mediodorsal (MD) and ventromedial (VM) thalamus, where layer 5 and 6 inputs activate thalamo-cortical (TC) neurons with distinct temporal profiles. We show that TC neurons in MD and VM in turn make distinct connections in PFC, with MD preferentially and strongly activating layer 2/3 cortico-cortical (CC) neurons. Finally, we assess local connections from superficial CC to deep CT neurons, which link thalamo-cortical and cortico-thalamic networks within the PFC. Together our findings indicate that PFC strongly drives neurons in the thalamus, whereas MD and VM indirectly influence reciprocally connected neurons in the PFC, providing a mechanistic understanding of these circuits.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009415 Nerve Net A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction. Neural Networks (Anatomic),Nerve Nets,Net, Nerve,Nets, Nerve,Network, Neural (Anatomic),Networks, Neural (Anatomic),Neural Network (Anatomic)
D009924 Organ Culture Techniques A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1) Organ Culture,Culture Technique, Organ,Culture Techniques, Organ,Organ Culture Technique,Organ Cultures
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017397 Prefrontal Cortex The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin. Anterior Prefrontal Cortex,Brodmann Area 10,Brodmann Area 11,Brodmann Area 12,Brodmann Area 47,Brodmann's Area 10,Brodmann's Area 11,Brodmann's Area 12,Brodmann's Area 47,Pars Orbitalis,Frontal Sulcus,Gyrus Frontalis Inferior,Gyrus Frontalis Superior,Gyrus Orbitalis,Gyrus Rectus,Inferior Frontal Gyrus,Lateral Orbitofrontal Cortex,Marginal Gyrus,Medial Frontal Gyrus,Olfactory Sulci,Orbital Area,Orbital Cortex,Orbital Gyri,Orbitofrontal Cortex,Orbitofrontal Gyri,Orbitofrontal Gyrus,Orbitofrontal Region,Rectal Gyrus,Rectus Gyrus,Straight Gyrus,Subcallosal Area,Superior Frontal Convolution,Superior Frontal Gyrus,Ventral Medial Prefrontal Cortex,Ventromedial Prefrontal Cortex,Anterior Prefrontal Cortices,Area 10, Brodmann,Area 10, Brodmann's,Area 11, Brodmann,Area 11, Brodmann's,Area 12, Brodmann,Area 12, Brodmann's,Area 47, Brodmann,Area 47, Brodmann's,Area, Orbital,Area, Subcallosal,Brodmanns Area 10,Brodmanns Area 11,Brodmanns Area 12,Brodmanns Area 47,Convolution, Superior Frontal,Convolutions, Superior Frontal,Cortex, Anterior Prefrontal,Cortex, Lateral Orbitofrontal,Cortex, Orbital,Cortex, Orbitofrontal,Cortex, Prefrontal,Cortex, Ventromedial Prefrontal,Cortices, Ventromedial Prefrontal,Frontal Convolution, Superior,Frontal Gyrus, Inferior,Frontal Gyrus, Medial,Frontal Gyrus, Superior,Frontalis Superior, Gyrus,Gyrus, Inferior Frontal,Gyrus, Marginal,Gyrus, Medial Frontal,Gyrus, Orbital,Gyrus, Orbitofrontal,Gyrus, Rectal,Gyrus, Rectus,Gyrus, Straight,Gyrus, Superior Frontal,Inferior, Gyrus Frontalis,Lateral Orbitofrontal Cortices,Olfactory Sulcus,Orbital Areas,Orbital Cortices,Orbital Gyrus,Orbitalis, Pars,Orbitofrontal Cortex, Lateral,Orbitofrontal Cortices,Orbitofrontal Cortices, Lateral,Orbitofrontal Regions,Prefrontal Cortex, Anterior,Prefrontal Cortex, Ventromedial,Prefrontal Cortices, Anterior,Region, Orbitofrontal,Subcallosal Areas,Sulcus, Frontal,Superior Frontal Convolutions,Superior, Gyrus Frontalis,Ventromedial Prefrontal Cortices
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D053444 Inhibitory Postsynaptic Potentials Hyperpolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during NEUROTRANSMISSION. They are local changes which diminish responsiveness to excitatory signals. IPSP,Inhibitory Postsynaptic Currents,Current, Inhibitory Postsynaptic,Currents, Inhibitory Postsynaptic,IPSPs,Inhibitory Postsynaptic Current,Inhibitory Postsynaptic Potential,Postsynaptic Current, Inhibitory,Postsynaptic Currents, Inhibitory,Postsynaptic Potential, Inhibitory,Postsynaptic Potentials, Inhibitory,Potential, Inhibitory Postsynaptic,Potentials, Inhibitory Postsynaptic
D062308 Optogenetics The combination of genetic and optical methods in controlling specific events with temporal precision in targeted cells of a functioning intact biological system. Optogenetic Techniques,Optogenetic,Optogenetic Technique,Technique, Optogenetic,Techniques, Optogenetic

Related Publications

David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Thalamic control of layer 1 circuits in prefrontal cortex.
December 2012, The Journal of neuroscience : the official journal of the Society for Neuroscience,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Two contrasting mediodorsal thalamic circuits target the mouse medial prefrontal cortex.
May 2024, Journal of neurophysiology,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Ventral tier thalamic nuclei.
January 1967, Modern trends in neurology,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
[Reciprocal relationships between the postero-medial ventral (PMV) thalamic nuclei of the two sides].
December 1967, Bollettino della Societa italiana di biologia sperimentale,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Thalamic afferents to prefrontal cortices from ventral motor nuclei in decision-making.
March 2019, The European journal of neuroscience,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Afferent connections to the ventral striatum from the medial prefrontal cortex (area 25) and the thalamic nuclei in the macaque monkey.
June 1999, Annals of the New York Academy of Sciences,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Disentangling the influences of multiple thalamic nuclei on prefrontal cortex and cognitive control.
September 2021, Neuroscience and biobehavioral reviews,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
Gray areas: Neuropeptide circuits linking the Edinger-Westphal and Dorsal Raphe nuclei in addiction.
October 2021, Neuropharmacology,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
[Functional interrelationship between the reticular and ventral anterior thalamic nuclei and the cerebral cortex].
January 1980, Fiziologicheskii zhurnal,
David P Collins, and Paul G Anastasiades, and Joseph J Marlin, and Adam G Carter
[Primary structural moduli of the dorsal thalamic nuclei and motor cortex in man].
January 2006, Morfologiia (Saint Petersburg, Russia),
Copied contents to your clipboard!