Ectopic ACTH production by a thymic carcinoid tumour. 1987

E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
Department of Paediatrics, General Hospital, Southampten, UK.

An ACTH-producing thymic carcinoid tumour was diagnosed in a 10-year-old girl, 8 years after bilateral adrenalectomy for Cushing's syndrome. The peptides produced by the tumour were characterised thoroughly. High circulating levels of beta-endorphin and other peptides may have contributed to mood and behaviour disturbances.

UI MeSH Term Description Entries
D009384 Paraneoplastic Endocrine Syndromes Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion. Ectopic Hormone Syndromes,Ectopic Hormone Syndrome,Endocrine Syndrome, Paraneoplastic,Paraneoplastic Endocrine Syndrome,Syndrome, Ectopic Hormone,Syndrome, Paraneoplastic Endocrine,Syndromes, Ectopic Hormone,Syndromes, Paraneoplastic Endocrine
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002276 Carcinoid Tumor A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182) Argentaffinoma,Carcinoid,Carcinoid, Goblet Cell,Argentaffinomas,Carcinoid Tumors,Carcinoids,Carcinoids, Goblet Cell,Goblet Cell Carcinoid,Goblet Cell Carcinoids,Tumor, Carcinoid,Tumors, Carcinoid
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003480 Cushing Syndrome A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent. Cushing's Syndrome,Hypercortisolism,Syndrome, Cushing,Syndrome, Cushing's
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000182 ACTH Syndrome, Ectopic Symptom complex due to ACTH production by non-pituitary neoplasms. Ectopic ACTH Syndrome,ACTH Syndromes, Ectopic,Ectopic ACTH Syndromes,Syndrome, Ectopic ACTH,Syndromes, Ectopic ACTH
D001615 beta-Endorphin A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN. Endorphin, beta,beta-Endorphin (1-31),beta Endorphin
D013953 Thymus Neoplasms Tumors or cancer of the THYMUS GLAND. Cancer of Thymus,Thymus Cancer,Thymus Tumors,Cancer of the Thymus,Neoplasms, Thymic,Neoplasms, Thymus,Thymic Cancer,Thymic Neoplasms,Thymic Tumors,Cancer, Thymic,Cancer, Thymus,Cancers, Thymic,Cancers, Thymus,Neoplasm, Thymic,Neoplasm, Thymus,Thymic Cancers,Thymic Neoplasm,Thymic Tumor,Thymus Cancers,Thymus Neoplasm,Thymus Tumor,Tumor, Thymic,Tumor, Thymus,Tumors, Thymic,Tumors, Thymus

Related Publications

E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
April 1996, Nihon Kyobu Shikkan Gakkai zasshi,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
January 2002, Acta clinica Belgica,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
April 2006, Journal of endocrinological investigation,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
July 2002, Clinical endocrinology,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
November 1997, Clinical endocrinology,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
May 2017, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
January 1999, Journal of pediatric endocrinology & metabolism : JPEM,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
January 1982, Journal of endocrinological investigation,
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
January 2013, Hormones (Athens, Greece),
E S McCaughey, and V Walker, and C J Rolles, and N I Scheurmier, and A C Hale, and L H Rees
February 1998, Clinical endocrinology,
Copied contents to your clipboard!