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Two human helper T cell determinants in influenza have been identified, one in the hemagglutinin and the other in the matrix protein (M1). Both were shown to be DR1 restricted by using transfected L cells to present antigen. Comparison of the sequences of the two peptides revealed a similar pattern that could account for their DR1 specificity if the peptides adopt a helical conformation. The model was supported by the demonstration that hybrid peptides, composed of the amino acids that interact with DR1 from one determinant and the residues that interact with the T cell receptor from the other, were recognized by each clone. The generality of the motif was confirmed by the finding that DR1 individuals respond to a ragweed peptide containing the defined pattern.
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
February 2006,
Arthritis and rheumatism,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
September 2003,
Human immunology,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
May 2012,
The Prostate,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
February 1984,
European journal of immunology,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
October 2010,
Infection and immunity,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
November 2017,
Haematologica,
J B Rothbard, and
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V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
October 1986,
BioEssays : news and reviews in molecular, cellular and developmental biology,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
June 1994,
Danish medical bulletin,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
September 1985,
Cellular immunology,
J B Rothbard, and
R I Lechler, and
K Howland, and
V Bal, and
D D Eckels, and
R Sekaly, and
E O Long, and
W R Taylor, and
J R Lamb
July 1991,
International immunology,
