BIOMAT Database Logo BIOMAT Database Logo

A Hepatocyte-Mimicking Antidote for Alcohol Intoxication. 2018

Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA, 90095, USA.

Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon alcohol consumption, alcohol is sequentially oxidized to acetaldehyde and acetate by the endogenous alcohol dehydrogenase and aldehyde dehydrogenase, respectively. Inspired by the metabolism of alcohol, a hepatocyte-mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. Administered to alcohol-intoxicated mice, the antidote rapidly accumulates in the liver and enables a significant reduction of the blood alcohol concentration. Moreover, blood acetaldehyde concentration is maintained at an extremely low level, significantly contributing to liver protection. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning and can provide therapeutic benefits.

UI MeSH Term Description Entries

Related Publications

Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
[Acute alcohol intoxication: physostigmine as an antidote for ethanol].
July 1978, Fortschritte der Medizin,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
Intracranial hemorrhage mimicking alcohol intoxication.
October 2021, Industrial psychiatry journal,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
Zitramin-a new antidote for acute ethanol intoxication.
January 2013, Doklady. Biochemistry and biophysics,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
Butyrylcholinesterase: an enzyme antidote for cocaine intoxication.
April 1998, Addiction biology,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
A specific antidote against lethal alkylphosphate intoxication.
January 1956, Archives of biochemistry and biophysics,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
[Antidote principles for ruminant intoxication of economic relevance].
August 1972, Monatshefte fur Veterinarmedizin,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
Nitrite as antidote for acute hydrogen sulfide intoxication?
November 1981, American Industrial Hygiene Association journal,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
A specific antidote for nerve gas and insecticide (alkylphosphate) intoxication.
April 1958, Neurology,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
Physostigmine, a highly potent antidote for acute experimental diazepam intoxication.
July 1978, Neuropharmacology,
Duo Xu, and Hui Han, and Yuxin He, and Harrison Lee, and Di Wu, and Fang Liu, and Xiangsheng Liu, and Yang Liu, and Yunfeng Lu, and Cheng Ji
Midazolam as an anticonvulsant antidote for organophosphate intoxication--A pharmacotherapeutic appraisal.
June 2015, Epilepsia,
Copied contents to your clipboard!