Biomaterial Database

Unexplained thromboembolism. When to suspect antithrombin III, protein C, or protein S deficiency. 1988

B D Scott

Department of Medicine, University of Oklahoma College of Medicine, Oklahoma City 73190.

Patients with recurrent or unusual thromboembolic events may have abnormalities in regulation of hemostasis because of inherited or acquired deficiencies of antithrombin III, protein C, or protein S. A working knowledge of the clotting process and a high degree of suspicion are needed to guide the clinician in this difficult diagnosis. Prompt and appropriate anticoagulant therapy can be lifesaving in these patients.

UI	MeSH Term	Description	Entries
D006023	Glycoproteins	Conjugated protein-carbohydrate compounds including MUCINS; mucoid, and AMYLOID glycoproteins.	C-Glycosylated Proteins,Glycosylated Protein,Glycosylated Proteins,N-Glycosylated Proteins,O-Glycosylated Proteins,Glycoprotein,Neoglycoproteins,Protein, Glycosylated,Proteins, C-Glycosylated,Proteins, Glycosylated,Proteins, N-Glycosylated,Proteins, O-Glycosylated
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013923	Thromboembolism	Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.	Thromboembolisms
D017293	Protein S	The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.	Vitamin K-Dependent Protein S,Cofactor Protein S,Protein S, Vitamin K-Dependent,Protein S, Cofactor,Protein S, Vitamin K Dependent,Vitamin K Dependent Protein S
D020151	Protein C Deficiency	An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)	Deficiency, Protein C,Hereditary Thrombophilia Due To Protein C Deficiency,Deficiencies, Protein C,Protein C Deficiencies
D020152	Antithrombin III Deficiency	An absence or reduced level of Antithrombin III leading to an increased risk for thrombosis.	Antithrombin 3 Deficiency,Congenital Antithrombin III Deficiency,Deficiency, Antithrombin III,Hereditary Antithrombin Deficiency,Antithrombin 3 Deficiencies,Antithrombin III Deficiencies,Deficiencies, Antithrombin 3,Deficiencies, Antithrombin III,Deficiency, Antithrombin 3