BIOMAT Database Logo BIOMAT Database Logo

A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. 1988

R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Department of Biochemistry, University of Massachusetts Medical Center, Worcester 01655.

Amino acid sequences deduced from rat complementary DNA clones encoding the insulin-like growth factor II (IGF-II) receptor closely resemble those of the bovine cation-independent mannose-6-phosphate receptor (Man-6-P receptorCI), suggesting they are identical structures. It is also shown that IGF-II receptors are adsorbed by immobilized pentamannosyl-6-phosphate and are specifically eluted with Man-6-P. Furthermore, Man-6-P specifically increases by about two times the apparent affinity of the purified rat placental receptor for 125I-labeled IGF-II. These results indicate that the type II IGF receptor contains cooperative, high-affinity binding sites for both IGF-II and Man-6-P-containing proteins.

UI MeSH Term Description Entries
D007335 Insulin-Like Growth Factor II A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults. IGF-II,Multiplication-Stimulating Activity,Somatomedin MSA,IGF-2,Insulin Like Growth Factor II,Insulin-Like Somatomedin Peptide II,Multiplication-Stimulating Factor,Somatomedin A,Factor, Multiplication-Stimulating,Insulin Like Somatomedin Peptide II,Multiplication Stimulating Activity,Multiplication Stimulating Factor
D008360 Mannosephosphates Phosphoric acid esters of mannose.
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D010920 Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES). Placentoma, Normal,Placentome,Placentas,Placentomes
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011972 Receptor, Insulin A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE. Insulin Receptor,Insulin Receptor Protein-Tyrosine Kinase,Insulin Receptor alpha Subunit,Insulin Receptor beta Subunit,Insulin Receptor alpha Chain,Insulin Receptor beta Chain,Insulin-Dependent Tyrosine Protein Kinase,Receptors, Insulin,Insulin Receptor Protein Tyrosine Kinase,Insulin Receptors
D002352 Carrier Proteins Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D002846 Chromatography, Affinity A chromatographic technique that utilizes the ability of biological molecules, often ANTIBODIES, to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Chromatography, Bioaffinity,Immunochromatography,Affinity Chromatography,Bioaffinity Chromatography
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA

Related Publications

R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II.
February 1988, The Journal of biological chemistry,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Mannose 6-phosphate/insulin-like growth factor II receptor: distinct binding sites for mannose 6-phosphate and insulin-like growth factor II.
February 1988, Biochemical and biophysical research communications,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
The kangaroo cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II with low affinity.
September 1999, The Journal of biological chemistry,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Dimerization of the insulin-like growth factor II/mannose 6-phosphate receptor.
June 2000, The Journal of biological chemistry,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
The insulin-like growth factor II/mannose-6-phosphate receptor : IGF-II/Man-6-P receptor.
December 1989, Cytotechnology,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Mannose-6-phosphate/insulin-like growth factor II receptor expression and tumor development.
February 2006, Bioscience reports,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Mannose 6-phosphate/insulin-like growth factor II-binding proteins in human serum and urine. Their relation to the mannose 6-phosphate/insulin-like growth factor II receptor.
June 1988, The Biochemical journal,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid.
December 1997, Proceedings of the National Academy of Sciences of the United States of America,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Domain interactions of the mannose 6-phosphate/insulin-like growth factor II receptor.
June 2005, The Journal of biological chemistry,
R G MacDonald, and S R Pfeffer, and L Coussens, and M A Tepper, and C M Brocklebank, and J E Mole, and J K Anderson, and E Chen, and M P Czech, and A Ullrich
Soluble insulin-like growth factor II/mannose 6-phosphate receptor inhibits DNA synthesis in insulin-like growth factor II sensitive cells.
January 2000, Journal of cellular physiology,
Copied contents to your clipboard!