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Repeated immunizations of rabbits with chemically synthesized peptides from selected regions of HLA-DP histocompatibility antigens resulted in the production of specific antibodies that were then isolated from the immune sera by chromatography on Sepharose-peptide immunoadsorbents. The purified antibodies, when tested with an enzyme-linked immunosorbent assay, specifically bound to the inciting fragments; moreover, two of them recognized glycoproteins extracted by nonionic detergents from human chronic lymphocytic leukemia cells, as revealed by binding assays. The results suggest that amino acid stretches 51-61 of the alpha chain and 80-90 of the beta chain of HLA-DP histocompatibility antigens are likely exposed on the surface of the protein molecule. The specific recognition of DP regions is strongly suggested by the difference in the binding of those antibodies to soluble membrane proteins, as compared to the binding of monomorphic anti-Class II monoclonal antibodies to the same antigens.
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
November 2005,
Journal of immunology (Baltimore, Md. : 1950),
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
March 1986,
Journal of immunology (Baltimore, Md. : 1950),
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
October 1991,
Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine,
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
January 2007,
Clinical transplants,
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
January 1983,
Nature,
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
April 1987,
Human immunology,
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
January 1965,
Federation proceedings,
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
May 1993,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
January 1990,
Immunogenetics,
A Chersi, and
R A Houghten, and
M C Morganti, and
E Muratti
December 1993,
Lancet (London, England),
