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It is now well recognized that pre-transplant donor-specific blood transfusion (DST) has a beneficial effect on the survival of allografts. To determine the optimal interval between DST and transplantation, and to analyze the mechanisms of this effect, the survival of cardiac allografts to rats which received a single DST was examined. The cardiac allograft survival was found to be prolonged when the DST was performed 1 to 6 weeks before grafting. In addition, recipient rat sera collected 1 to 6 weeks after a single DST showed significant inhibition of a mixed lymphocyte reaction (MLR). This MLR inhibition correlated with prolongation of survival of histoincompatible rat cardiac allografts. It thus appears that a single DST given from 1 to 6 weeks before transplantation has a beneficial effect on allograft survival and that MLR inhibition may be essential for inducing the effect of transfusion on organ transplantation.
K Tanaka, and
K Sakagami, and
K Orita
January 1986,
Transplantation,
K Tanaka, and
K Sakagami, and
K Orita
March 1988,
Transplantation,
K Tanaka, and
K Sakagami, and
K Orita
June 1988,
Transplantation proceedings,
K Tanaka, and
K Sakagami, and
K Orita
December 1991,
Transplantation proceedings,
K Tanaka, and
K Sakagami, and
K Orita
July 1992,
Transplantation,
K Tanaka, and
K Sakagami, and
K Orita
February 1996,
The Journal of surgical research,
K Tanaka, and
K Sakagami, and
K Orita
January 1985,
The Journal of heart transplantation,
K Tanaka, and
K Sakagami, and
K Orita
October 1984,
The Japanese journal of experimental medicine,
K Tanaka, and
K Sakagami, and
K Orita
March 2000,
Journal of immunology (Baltimore, Md. : 1950),
K Tanaka, and
K Sakagami, and
K Orita
February 1989,
Transplantation proceedings,
