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The effects of the diphosphonates etidronate and clodronate were studied in 144 patients with Paget's disease. All five programmes of treatment tested induced a similar suppression of disease activity as judged by serum alkaline phosphatase concentrations, but the proportion of patients responding and the duration of responses differed significantly between programmes. The proportion responding to etidronate 5-10 mg/kg/day for six months was less than for other regimens, and the most sustained response was after treatment with clodronate 1600 mg daily for six months. More complete biochemical suppression was associated with the more prolonged responses irrespective of the regimen used.
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
January 1977,
The Journal of clinical endocrinology and metabolism,
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
February 1994,
Seminars in arthritis and rheumatism,
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
August 1976,
Calcified tissue research,
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
March 1976,
Lancet (London, England),
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
February 1996,
Bone,
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
May 1974,
The American journal of roentgenology, radium therapy, and nuclear medicine,
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
January 1984,
Metabolic bone disease & related research,
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
February 1975,
British medical journal,
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
September 1979,
Lancet (London, England),
R E Gray, and
A J Yates, and
C J Preston, and
R Smith, and
R G Russell, and
J A Kanis
October 1976,
Clinical orthopaedics and related research,
