BIOMAT Database Logo BIOMAT Database Logo

Relation of concentric left ventricular hypertrophy and extracardiac target organ damage to supranormal left ventricular performance in established essential hypertension. 1988

J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021.

Increased cardiac performance has been documented in patients with early systemic hypertension, but its prevalence and determinants in patients with uncomplicated sustained essential hypertension have not been characterized. Radionuclide cineangiography in 116 patients with uncomplicated essential hypertension showed that 12 of 116 (10%) had supranormal resting left ventricular (LV) ejection fraction (greater than 70%, above the highest value in normal subjects), while 104 patients had a normal resting ejection fraction (45 to 70%). Patients with a high resting ejection fraction had higher systolic and diastolic blood pressure compared with patients with normal resting ejection fraction (182 mm Hg vs 169, p less than 0.01, and 110 vs 103, p less than 0.05, respectively), markedly greater echocardiographic LV mass (136 vs 94 g/m2, p less than 0.01), smaller ventricular dimensions in systole (2.5 vs 3.1, p less than 0.01) and diastole (4.4 vs 4.9, p less than 0.05), and higher relative wall thickness (0.61 +/- 0.20 vs 0.39 +/- 0.98, p less than 0.001). Patients with supranormal resting ventricular performance had lower end-systolic wall stress than normal volunteers or patients with normal resting LV function (48 vs 64 vs 74 X 10(3) dynes/cm2, respectively). Patients with an elevated LV ejection fraction also had significantly more abnormal funduscopic examinations and greater proteinuria. Thus, a subset of essential hypertensive patients with moderately to severely elevated blood pressure developed marked concentric LV hypertrophy associated with subnormal end-systolic stress and supranormal LV performance.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D004452 Echocardiography Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic. Echocardiography, Contrast,Echocardiography, Cross-Sectional,Echocardiography, M-Mode,Echocardiography, Transthoracic,Echocardiography, Two-Dimensional,Transthoracic Echocardiography,2-D Echocardiography,2D Echocardiography,Contrast Echocardiography,Cross-Sectional Echocardiography,Echocardiography, 2-D,Echocardiography, 2D,M-Mode Echocardiography,Two-Dimensional Echocardiography,2 D Echocardiography,Cross Sectional Echocardiography,Echocardiography, 2 D,Echocardiography, Cross Sectional,Echocardiography, M Mode,Echocardiography, Two Dimensional,M Mode Echocardiography,Two Dimensional Echocardiography
D005080 Exercise Test Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. Arm Ergometry Test,Bicycle Ergometry Test,Cardiopulmonary Exercise Testing,Exercise Testing,Step Test,Stress Test,Treadmill Test,Cardiopulmonary Exercise Test,EuroFit Tests,Eurofit Test Battery,European Fitness Testing Battery,Fitness Testing,Physical Fitness Testing,Arm Ergometry Tests,Bicycle Ergometry Tests,Cardiopulmonary Exercise Tests,Ergometry Test, Arm,Ergometry Test, Bicycle,Ergometry Tests, Arm,Ergometry Tests, Bicycle,EuroFit Test,Eurofit Test Batteries,Exercise Test, Cardiopulmonary,Exercise Testing, Cardiopulmonary,Exercise Tests,Exercise Tests, Cardiopulmonary,Fitness Testing, Physical,Fitness Testings,Step Tests,Stress Tests,Test Battery, Eurofit,Test, Arm Ergometry,Test, Bicycle Ergometry,Test, Cardiopulmonary Exercise,Test, EuroFit,Test, Exercise,Test, Step,Test, Stress,Test, Treadmill,Testing, Cardiopulmonary Exercise,Testing, Exercise,Testing, Fitness,Testing, Physical Fitness,Tests, Arm Ergometry,Tests, Bicycle Ergometry,Tests, Cardiopulmonary Exercise,Tests, EuroFit,Tests, Exercise,Tests, Step,Tests, Stress,Tests, Treadmill,Treadmill Tests
D005260 Female Females
D006321 Heart The hollow, muscular organ that maintains the circulation of the blood. Hearts
D006332 Cardiomegaly Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. Cardiac Hypertrophy,Enlarged Heart,Heart Hypertrophy,Heart Enlargement,Cardiac Hypertrophies,Enlargement, Heart,Heart Hypertrophies,Heart, Enlarged,Hypertrophies, Cardiac,Hypertrophies, Heart,Hypertrophy, Cardiac,Hypertrophy, Heart

Related Publications

J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension.
June 2002, Journal of human hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Extracardiac organ damage in essential hypertensives with left ventricular concentric remodelling.
June 2010, Journal of human hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Left ventricular geometry as an independent predictor for extracardiac target organ damage in essential hypertension.
October 1998, American journal of hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Assessment of preclinical target organ damage in hypertension: left ventricular hypertrophy.
December 2001, Journal of hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Assessment of preclinical target organ damage in hypertension: left ventricular hypertrophy.
January 2002, Journal of hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Relation between left ventricular geometric alteration and extracardiac target organ damage in hypertensive patients.
July 2000, Hypertension research : official journal of the Japanese Society of Hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Clinical evidence for an association between left ventricular geometric adaptation and extracardiac target organ damage in essential hypertension.
January 1995, Journal of hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Relation of left ventricular hypertrophy and geometry to asymptomatic cerebrovascular damage in essential hypertension.
February 1999, The American journal of cardiology,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in Goldblatt hypertension.
May 1992, American journal of hypertension,
J Blake, and R B Devereux, and E M Herrold, and M Jason, and J Fisher, and J S Borer, and J H Laragh
Assessment of preclinical target organ damage in hypertesion: left ventricular hypertrophy.
January 2003, Blood pressure,
Copied contents to your clipboard!