Biomaterial Database

SUBLINGUAL IMMUNOTHERAPY FOR ALLERGIC ASTHMA AND RHINITIS. 2018

A A Telia, and A Z Telia, and K Machavariani, and Z Telia

Tbilisi State Medical University, Department of Allergology and Clinical Immunology, Georgia.

The purpose of our study was to perform a meta-analysis and thus, based on original randomized placebo-controlled studies, evaluate the effectiveness and safety of sublingual immunotherapy (SLIT) in children and adults suffering from allergic bronchial asthma and rhinitis. On the MEDLINE, EMBASE, LILACS and SCOPUS web pages, the corresponding experimental works were searched. After an expert evaluation, 58 case-studies were selected 38. Of these, 30 concerned the efficacy and safety of sublingual immunotherapy of allergic rhinitis, and 8 of bronchial asthma. In active groups, 347 patients with asthma and 1888 rhinitis were involved, and in the control groups, respectively, 332 and 1795 subjects studied. There were 7 different meta-analytical comparisons based on the purpose of our study. Our Meta-analytic study on the selected publications have been shown that sublingual immunotherapy in children and adults suffering from allergic bronchial asthma and rhinitis is effective and safe. However, based on the low evidentiary level and high heterogeneity of the publication that we used in the meta-analysis, unambiguous recommendations regarding the advisability of using the sublingual immunotherapy method in patients with allergic rhinitis and asthma are premature. For all these reasons, the results of this analysis should be interpreted by the various selected population subgroups, following specific recommendations addressed to unified results, endpoints, time points, measurement scales and dosages, treatment distribution and power calculation. Despite our results, we believe that there are arguments indicating that SLIT may be a promising direction in the treatment of allergic rhinitis and asthma, but it should not be prescribed regularly to all patients.

UI	MeSH Term	Description	Entries
D007167	Immunotherapy	Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.	Immunotherapies
D006255	Rhinitis, Allergic, Seasonal	Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.	Hay Fever,Pollen Allergy,Pollinosis,Seasonal Allergic Rhinitis,Hayfever,Allergic Rhinitides, Seasonal,Allergic Rhinitis, Seasonal,Allergies, Pollen,Allergy, Pollen,Fever, Hay,Pollen Allergies,Pollinoses,Rhinitides, Seasonal Allergic,Rhinitis, Seasonal Allergic,Seasonal Allergic Rhinitides
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000286	Administration, Sublingual	Administration of a soluble dosage form by placement under the tongue.	Drug Administration, Sublingual,Sublingual Drug Administration,Sublingual Administration,Administration, Sublingual Drug,Administrations, Sublingual,Administrations, Sublingual Drug,Drug Administrations, Sublingual,Sublingual Administrations,Sublingual Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001249	Asthma	A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	Asthma, Bronchial,Bronchial Asthma,Asthmas
D016032	Randomized Controlled Trials as Topic	Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.	Clinical Trials, Randomized,Controlled Clinical Trials, Randomized,Trials, Randomized Clinical
D039981	Pyroglyphidae	Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.	Dermatophagoides,Dust Mites, House,House Dust Mites,Mites, House Dust,Euroglyphus,Housedust Mites,Dermatophagoide,Dust Mite, House,House Dust Mite,Housedust Mite,Mite, House Dust,Mite, Housedust,Mites, Housedust
D065631	Rhinitis, Allergic	An inflammation of the NASAL MUCOSA triggered by ALLERGENS.	Allergic Rhinitis,Allergic Rhinitides,Rhinitides, Allergic