BIOMAT Database Logo BIOMAT Database Logo

[Association between high-sensitivity C-reactive protein and both cardiovascular, total mortality events in middle-aged Chinese adults]. 2018

Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Division of Prevention and Community Health, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 102308, China.

Objective: To estimate the association between high-sensitivity C-reactive protein (hs-CRP) and cardiovascular events as well as all-cause mortality events. Methods: During 2009- 2010, out of the 11 623 individuals, 1 000 participants aged 35-64 years, were recruited and divided into 12 age-groups, to have received a study on CVD risk factors. Information on the risk factors of cardiovascular diseases was also collected. Fasting blood sample was gathered for all the participants, with hs-CRP tested. Participants in 7 out of the 12 sites were followed, with 6.21 years (36 075 person-years) as the median follow-up period. Cardiovascular and all-cause mortality events were collected. A total of 6 177 participants had been followed after excluding participants who had baseline infections, or did not take hs-CRP test/physical examination at the baseline. Finally, 5 984 participants were included for analysis. Participants were categorized into three groups based on the hs-CRP (mg/L) values: <1, 1-3 and >3, respectively. Cox proportional hazards regression model was used to analyze the relationships between hs-CRP with cardiovascular events or all-cause mortality events, after adjusting for confounding factors. Results: Mean age of the participants was 50.2 years. The incidence rates of cardiovascular disease events were 3.6/1 000 person-years, 7.1/1 000 person-years,and 10.4/1 000 person-years among three groups and 3.0/1 000 person-years, 5.7/1 000 person-years, 9.1/1 000 person-years for all-cause mortality events, respectively. After adjusting for confounding factors, the hazard risks (HR) for cardiovascular events were 1.33 (95%CI: 0.95-1.84) in the hs-CRP 1-3 mg/L group and 1.76 (95%CI: 1.20-2.60) in the hs-CRP>3 mg/L group when comparing with the hs-CRP<1 mg/L group (trend test P=0.003). The HRs for all-cause mortality events were 1.76 (95%CI: 1.23-2.54) and 2.64 (95%CI: 1.74-4.01) (trend test P<0.001), respectively. Conclusion: Hs-CRP appeared an independent predictor for cardiovascular events and all-cause mortality events.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002097 C-Reactive Protein A plasma protein that circulates in increased amounts during inflammation and after tissue damage. C-Reactive Protein measured by more sensitive methods often for coronary heart disease risk assessment is referred to as High Sensitivity C-Reactive Protein (hs-CRP). High Sensitivity C-Reactive Protein,hs-CRP,hsCRP,C Reactive Protein,High Sensitivity C Reactive Protein
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D015994 Incidence The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases in the population at a given time. Attack Rate,Cumulative Incidence,Incidence Proportion,Incidence Rate,Person-time Rate,Secondary Attack Rate,Attack Rate, Secondary,Attack Rates,Cumulative Incidences,Incidence Proportions,Incidence Rates,Incidence, Cumulative,Incidences,Person time Rate,Person-time Rates,Proportion, Incidence,Rate, Attack,Rate, Incidence,Rate, Person-time,Rate, Secondary Attack,Secondary Attack Rates

Related Publications

Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Association of Serum Total Bilirubin with Serum High Sensitivity C-reactive Protein in Middle-aged Men.
September 2011, Korean journal of family medicine,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Association between high-sensitivity C-reactive protein and coronary atherosclerosis in a general middle-aged population.
July 2023, Scientific reports,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Serum C-reactive protein and risk of cardiovascular events in middle-aged and older chinese population.
June 2009, The American journal of cardiology,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Cross-Sectional Association Between Number of Teeth and High-Sensitivity C-Reactive Protein Among Middle-Aged Germans.
March 2016, Journal of periodontology,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Association Between High-sensitivity C-reactive Protein and Predicted Cardiovascular Risks in Schizophrenia.
March 2023, Alternative therapies in health and medicine,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Association between fasting insulin and high-sensitivity C reactive protein in Korean adults.
January 2017, BMJ open sport & exercise medicine,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Distribution of High-Sensitivity C-Reactive Protein and Its Relationship with Other Cardiovascular Risk Factors in the Middle-Aged Chinese Population.
August 2016, International journal of environmental research and public health,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
High-sensitivity C-reactive protein and cystatin C independently and jointly predict all-cause mortality among the middle-aged and elderly Chinese population.
March 2019, Clinical biochemistry,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
High sensitivity C-reactive protein associated with different health predictors in middle-aged and oldest old Chinese.
June 2012, Biomedical and environmental sciences : BES,
Y Dong, and Z W Wang, and X Wang, and Y Tian, and L F Zhang, and Z Chen, and H Q Cao
Association between high-sensitivity C-reactive protein and hyperuricemia.
April 2016, Rheumatology international,
Copied contents to your clipboard!