To assess the therapeutic effect of mucopolysaccharide polysulfate cream in prevention of postoperative scars.
 Methods: One hundred postoperative patients were divided into an experimental group and a control group (each n=50). After stitch removal, the experimental group wiped mucopolysaccharide polysulfate cream, and the control group wiped urea cream. The scars of the two groups were evaluated by Vancouver Scar Scale (VSS) on the day of stitch removal and in the 4th, 8th, 12th, 16th, 20th, 24th, 28th, and 32th weeks during the treat process.
 Results: At the beginning of treatment, the total VSS scores in the experimental group were always lower than that in the control group (P<0.05). There was no difference between the two groups in the color scores at each time point of follow-up (P>0.05). Form the 20th week, the vascular distribution scores in the experimental group were lower than that in the control group (P<0.05). And the thickness and flexibility scores in the experimental group were lower at each time point of follow-up (P<0.05). There were no differences between the two groups in wounds in head, face, or neck in the total VSS scores and all index scores (P>0.05), and the total VSS scores in the experimental group, who had wounds in chest, shoulder, or back, or had wounds in waist, abdomen, or hip, or had wounds in extremity, were lower than that in the control group (P<0.05). The vascular distribution and thickness scores in the experimental group, who had wounds in chest, shoulder, or back, were better than that in the control group (P<0.05). 
 Conclusion: Wiping mucopolysaccharide polysulfate cream after operation as soon as possible can effectively prevent scar hyperplasia, and it is worth to be widely applied in clinic.