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1. Eight normal volunteers were infused with 5% saline (5 g of NaCl/100 ml) at a rate of 0.06 ml min-1 kg-1 for 120 min to increase plasma osmolality and plasma arginine vasopressin. Human atrial natriuretic peptide (alpha-hANP; 100 micrograms) or placebo was given in random order in a double-blind cross-over design for the last 20 min of the saline infusion. 2. Compared with the placebo infusion, atrial natriuretic peptide (ANP) produced a 43% greater sodium excretion and a 34% greater urinary volume in the subsequent hour. 3. Mean plasma immunoreactive ANP did not increase in response to changes in osmolality and rose to a peak of 118 pg/ml during the alpha-hANP infusion. alpha-hANP produced significant suppression of mean plasma arginine vasopressin over the 60 min after the infusions. 4. We conclude that ANP is not released in response to increased osmolality in vivo, and that it inhibits osmolality-induced arginine vasopressin release in man.
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
February 1987,
Clinical endocrinology,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
March 1989,
The American journal of physiology,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
March 1991,
The American journal of physiology,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
September 1988,
The American journal of physiology,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
March 1985,
Neuroendocrinology,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
January 1988,
Nephron,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
May 1988,
Acta endocrinologica,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
January 1990,
Mineral and electrolyte metabolism,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
August 1993,
Acta psychiatrica Scandinavica,
M J Allen, and
V T Ang, and
E D Bennett, and
J S Jenkins
January 1995,
Journal of psychiatric research,
