BIOMAT Database Logo BIOMAT Database Logo

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. 1988

J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
UNICET, Laboratory for Immunological Research, Dardilly, France.

The effect of human recombinant interleukin 4 (IL-4) on antibody production by normal peripheral blood mononuclear cells enriched for B cells was investigated. IL-4 preferentially induced IgE synthesis in vitro. In addition, a low induction of IgG production was observed, whereas IL-4 had no effect on IgA and IgM synthesis. The IL-4-induced IgE production by B cells required T cells and monocytes but was specifically inhibited by an anti-IL-4 antiserum indicating that, although IL-4 acts indirectly, it is responsible for the induction of IgE synthesis. IL-4-induced IgE production was blocked in a dose-dependent way by interferon gamma (IFN-gamma), interferon alpha (IFN-alpha), and prostaglandin E2. IFN-gamma also inhibited IL-4-induced IgG production. These inhibitory effects of IFN-gamma and IFN-alpha on IgE production cannot be attributed to toxic effects since IFN-alpha induced IgM production in the presence of IL-4, whereas IFN-gamma was ineffective in inhibiting IgG production induced by IL-2. IFN-gamma, IFN-alpha, and prostaglandin E2 also inhibited IL-4-induced expression of the low-affinity receptor for the Fc portion of IgE (CD23) on B cells, indicating that there is an association between CD23 expression and IL-4-induced IgE production. This theory was supported by the finding that IL-4-induced IgE production was inhibited by F(ab')2 fragments of an anti-CD23 monoclonal antibody.

UI MeSH Term Description Entries
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D007370 Interferon Type I Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA). Interferons Type I,Type I Interferon,Type I Interferons,Interferon, Type I,Interferons, Type I
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D007378 Interleukins Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli. Interleukin
D008214 Lymphocytes White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D011458 Prostaglandins E (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities. PGE
D011961 Receptors, Fc Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules. Fc Receptors,Fc Receptor,Receptor, Fc
D011994 Recombinant Proteins Proteins prepared by recombinant DNA technology. Biosynthetic Protein,Biosynthetic Proteins,DNA Recombinant Proteins,Recombinant Protein,Proteins, Biosynthetic,Proteins, Recombinant DNA,DNA Proteins, Recombinant,Protein, Biosynthetic,Protein, Recombinant,Proteins, DNA Recombinant,Proteins, Recombinant,Recombinant DNA Proteins,Recombinant Proteins, DNA
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes.
July 1993, European journal of immunology,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.
July 1989, Proceedings of the National Academy of Sciences of the United States of America,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Interleukin-1beta-induced prostaglandin E2 production by human gingival fibroblasts is upregulated by glycine.
July 2005, Journal of periodontology,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
In vitro IgE production by interleukin 4-stimulated human peripheral blood mononuclear cells is suppressed by rapamycin.
December 1991, Clinical immunology and immunopathology,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Stimulation of prostaglandin E2 synthesis by interleukin-1beta is amplified by interferons but inhibited by interleukin-4 in human amnion-derived WISH cells.
January 1996, Biochimica et biophysica acta,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Leukotriene B4 enhances IL-4-induced IgE production from normal human lymphocytes.
June 1994, Cellular immunology,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Prostaglandin E2 potentiates interleukin-1 beta induced interleukin-6 production by human gingival fibroblasts.
July 1996, Journal of clinical periodontology,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Effects of interferons-alpha, -beta, and -gamma on human interleukin-2 production.
October 1986, Journal of interferon research,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Functional interaction between interleukin-9/P40 and interleukin-4 in the induction of IgE production by normal human B lymphocytes.
January 1993, Biotechnology therapeutics,
J Pène, and F Rousset, and F Brière, and I Chrétien, and J Y Bonnefoy, and H Spits, and T Yokota, and N Arai, and K Arai, and J Banchereau
Thrombin-induced interleukin-8 production and its regulation by interferon-gamma and prostaglandin E2 in human monocytic U937 cells.
April 1999, Immunology letters,
Copied contents to your clipboard!