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The infection of mice with Trypanosoma cruzi has been used as an experimental model for human Chagas disease, because the murine and human infections have similar acute and chronic phases generating similar immunopathological phenomena. Histopathological studies of murine tissues showed that the inflammatory lesions were small during the acute phase and composed mainly of mononuclear cells. During the chronic phase, cellular infiltrates were clustered in large granulomata consisting of mononuclear and polynuclear neutrophil cells. Characterization of the infiltrating cells by surface markers showed that about 6% were Thyl.2+ T cells, and CD4+(Lyt 1+) T cells (T helper/DTH subset) were more numerous than CD8+(Lyt 2+) T cells. These observations suggest that delayed type hypersensitivity plays a role in the pathology of Chagas disease.
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
January 1976,
Revista do Instituto de Medicina Tropical de Sao Paulo,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
May 2016,
Cell death & disease,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
August 2003,
The Journal of parasitology,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
June 2003,
International journal of hematology,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
January 2010,
Cell research,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
February 1999,
International immunology,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
January 2012,
PloS one,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
January 1980,
Advances in parasitology,
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
September 2009,
Journal of immunology (Baltimore, Md. : 1950),
A Ben Younès-Chennoufi, and
G Said, and
H Eisen, and
A Durand, and
M Hontebeyrie-Joskowicz
October 1990,
Infection and immunity,
