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Menogaril, a new semisynthetic anthracycline antibiotic, was administered to 35 patients with advanced colorectal cancer. The drug was infused over 2 hr at a dose of 160 mg/sqm or 200 mg/sqm repeated every 4 weeks. Twenty-seven patients were evaluable for response and no objective responses were achieved. Myelosuppression, only leukopenia, was usually of mild-moderate degree and occurred in 63% of the patients. Twenty-seven percent of the patients experienced severe leukopenia. Local erythema and phlebitis were frequently observed and were severe in 13% of the patients. Nausea/vomiting (66%) and alopecia (50%) were. of mild-moderate degree. This study suggests that menogaril at these doses and schedule had no activity in advanced colorectal cancer.
E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
September 1987,
Cancer treatment reports,
E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
November 1987,
European journal of cancer & clinical oncology,
E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
November 1982,
Cancer treatment reports,
E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
January 1990,
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E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
August 1981,
European journal of cancer & clinical oncology,
E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
September 1988,
Journal of the National Cancer Institute,
E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
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G Renard, and
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August 1991,
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E E Holdener, and
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G Decoster, and
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August 1990,
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G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
October 1987,
Cancer treatment reports,
E E Holdener, and
W W ten Bokkel Huinink, and
G Decoster, and
C Ludwig, and
G Renard, and
H M Pinedo
June 1987,
Cancer treatment reports,
