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Three new C19-norditerpenoid alkaloids (1⁻3), along with two known C19-norditerpenoid alkaloids (4,5), have been isolated from Aconitum szechenyianum. Based on extensive spectroscopic techniques (1D, 2D-NMR, IR, and MS) and chemical methods, their structures were established as szechenyianine D (1), szechenyianine E (2), szechenyianine F (3), 8-O-methyl-14-benzoylaconine (4), and spicatine A (5). The immunosuppressive effects of compounds 1⁻5 were studied using a ConA-induced or LPS-induced splenocyte proliferation model. In vitro tests showed that Compounds 2, 4, and 5 suppressed ConA-induced or LPS-induced splenocyte proliferation in a concentration-dependent manner. The CC50/IC50 values of 2, 4, and 5 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis.
Bei Song, and
Bingliang Jin, and
Yuze Li, and
Fei Wang, and
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Xiaomei Song, and
Zhenggang Yue, and
Jianli Liu
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Bei Song, and
Bingliang Jin, and
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Jianli Liu
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Natural product research,
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Planta medica,
Bei Song, and
Bingliang Jin, and
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Fei Wang, and
Yifu Yang, and
Yuwen Cui, and
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Zhenggang Yue, and
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December 2002,
Planta medica,
Bei Song, and
Bingliang Jin, and
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Journal of natural medicines,
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Bingliang Jin, and
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Zhenggang Yue, and
Jianli Liu
January 2001,
Journal of Asian natural products research,
Bei Song, and
Bingliang Jin, and
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Yuwen Cui, and
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Jianli Liu
February 2003,
Journal of natural products,
Bei Song, and
Bingliang Jin, and
Yuze Li, and
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Jianli Liu
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Chemical & pharmaceutical bulletin,
