The benefits of vaccines for adults have been underappreciated because of the focus on childhood vaccines. However, precisely because of the success of immunization programs for children, most deaths from vaccine-preventable diseases now occur amongst adults. Tetanus boosters will help to maintain Canada's low tetanus rates and pertussis boosters for adults are now available. Human papilloma virus vaccine may be indicated in some older adults. Hepatitis A and B vaccines may be indicated if there is occupational, travel or lifestyle risk. Pneumococcal and zoster vaccines are recommended in those over 65 years of age, and all adults benefit from annual influenza vaccination. A systematic approach to immunizing adults would assist in ensuring that all who are eligible for specific vaccines are offered them. This approach would include promoting routine immunization as a fundamental part of every patient encounter and the use of tools, such as the Adult Immunization Questionnaire and the Adult Immunization Wallet Card. By investing in these strategies, the health of adults can be improved significantly.