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The antiproliferative effects of the fluoropyrimidine derivatives, 5-fluorouracil (5-FU), 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur), UFT, 1-hexylcarbamoyl-5-fluorouracil (HCFU), and 5'-deoxy-5-fluorouracil (5'DFUR), were investigated in a 4 day subrenal capsule assay. The antiproliferative effects against two human tumor xenografts established in athymic mice were examined after treatment with three different doses of each anticancer agent, and the adequate dose of each anticancer agent in this experimental system was estimated as: 473 mg/kg for Tegafur, 433 mg/kg for UFT, 50 mg/kg for HCFU and 185 mg/kg for 5'DFUR, respectively. A comparative study of the antiproliferative effects of fluoropyrimidine derivatives was carried out against 7 xenografts. According to our criteria of positive tumor response, the effective rates were: 1 of 7 (14.3 per cent) by 5-FU, 2 of 7 (28.6 per cent) by Tegafur, 2 of 7 (28.6 per cent) by UFT, 1 of 6 (16.7 per cent) by HCFU, and 1 of 4 (25.0 per cent) by 5'DFUR, respectively. Although no statistical differences were demonstrated between the agents, the utility of a chemosensitivity test before clinical use was suggested.
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
September 1987,
Zhonghua yi xue za zhi,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
October 1985,
European journal of cancer & clinical oncology,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
January 1991,
Neoplasma,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
January 1988,
Progress in clinical and biological research,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
November 1987,
Nihon Geka Gakkai zasshi,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
July 1986,
The Japanese journal of surgery,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
January 1988,
Nihon Gan Chiryo Gakkai shi,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
January 1988,
Journal of medicine,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
January 1987,
Oncology,
M Nishiyama, and
S Takagami, and
Y Kirihara, and
T Saeki, and
N Hirabayashi, and
Y Nosoh, and
M Niimoto, and
T Hattori
September 1986,
European journal of cancer & clinical oncology,
