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The effect of human atrial natriuretic peptide (hANP) on aldosterone, 18-OH-cortisterone, corticosterone, deoxycorticosterone, and cortisol secretion was examined in isolated human aldosteronoma cells from five patients with primary aldosteronism. hANP exerted a nearly identical inhibitory action on basal secretion of each of these steroids and antagonized also the stimulating effects of ACTH, serotonin, metoclopramide and vasoactive intestinal polypeptide. The results suggest that in human aldosteronoma cells hANP may be a non-selective inhibitor of corticosteroid biosynthesis and that the site of inhibition of steroidogenesis may be localized to the early pathway of steroid biosynthesis.
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K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
March 1991,
Fukuoka igaku zasshi = Hukuoka acta medica,
E Gláz, and
K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
July 1987,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
E Gláz, and
K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
October 1985,
The Journal of clinical endocrinology and metabolism,
E Gláz, and
K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
July 1986,
The Journal of clinical endocrinology and metabolism,
E Gláz, and
K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
November 1994,
Biochemical and biophysical research communications,
E Gláz, and
K Rácz, and
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L Fútó, and
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Z Schaff
June 1995,
Molecular and cellular endocrinology,
E Gláz, and
K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
May 1986,
Clinical science (London, England : 1979),
E Gláz, and
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O Sergev, and
L Fútó, and
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Z Schaff
April 1996,
Molecular and cellular endocrinology,
E Gláz, and
K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
June 1991,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
E Gláz, and
K Rácz, and
I Varga, and
R Kiss, and
O Sergev, and
L Fútó, and
A Szécsény, and
Z Schaff
January 1987,
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao,
